Preliminary study on the toxicological impacts of Pinus roxburghii and Nauplius graveolens extracts on albino mice

The objective of this study was to evaluate the potential toxicity methanolic extracts Pinus roxburghii branch (P. roxburghii) and Nauplius graveolens (N. graveolens). Single oral dosage administered male mice at increasing concentrations 100, 250,500,1000 2000 mg/kg body weight assess median LD50, which causes death 50% (one half) mice. Blood samples were collected end 14 day toxicological trial for liver kidney function tests. results showed that LD50 P. 1708.3 mg/ kg N. 1562.5 weight. acute had detrimental effects on function. Based finding, a second designed, after intragastrically one tenth (1/10) each plant extract whole month. At termination 30-day trial, blood organs long-term administration 1/10 dosages no significant adverse neither functions nor histopathological examination. In conclusion, further studies are warranted determine application these as natural therapeutic products.